Omeshal-D (Domperidone & Omeprazole) X10 Tablets

Description

1. Omeshal D:
   • Uses:
     • Stimulation of gut motility in:
       • Non-ulcer dyspepsia
       • Oesophageal reflux, reflux oesophagitis, and gastritis
       • Diabetic gastroparesis
       • Functional dyspepsia
       • Speeding barium transit in follow-through radiological studies
       • Prevention and symptomatic relief of acute nausea and vomiting from any cause, including cytotoxic therapy, radiotherapy, and antiparkinsonism therapy
       • Prophylactic treatment of migraine
     • Associated treatment for these conditions:
       • Diabetic Gastroparesis
       • Dyspepsia
       • Erosive Esophagitis
       • Gastrointestinal Symptoms
       • Non-erosive Reflux Esophagitis Disease (NERD)
       • Upper gastrointestinal motility disorders
   • Dosage:
     • Adults: 10 – 20 mg every 4 – 8 hours daily
     • Children: 0.2 – 0.4 mg/kg every 4 – 8 hours daily
     • Domperidone tablet and suspension should be taken 15 – 30 minutes before a meal.
     • For acute nausea and vomiting, the maximum period of treatment is 12 weeks.
   • Side Effects:
     • Domperidone may produce hyperprolactinemia, which may cause galactorrhea, breast enlargement, soreness, and reduced libido.
     • Rare side effects include dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash, and itching.
2. Omeshal:
   • Uses:
     • Omeshal belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell.
     • It is used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults.
     • Prescription Omeshal is used to allow the esophagus to heal and prevent further damage to the esophagus in adults and children 1 year of age and older with GERD.
   • Effects on Gastric Acid Secretion:
     • This drug decreases gastric acid secretion.
     • After oral administration, the onset of the antisecretory effect of omeprazole is usually achieved within one hour, with the maximum effect occurring by 2 hours after administration.