Description
Clartem QS Is A Drug That Contains Artemeter 80mg And Lumefantrine 480mg As Its Active Ingredient. It Is A Combination Medicine That Contains Two Drugs To Make It More Effective.
It is a combination of artemther and lumefantrine, which act as a blood schizontocide.
It is indicated for the treatment of adults and children with acute,
uncomplicated infections due to Plasmodium falciparum or mixed infection including
P. Falciparium and strains from multi drug resistant areas.
CLARTEM 80/480 is recommended for use as a standby emergency treatment for
travellers to area where the Parasite is resistant to other drugs.
It is contraindicated in:
patients with known hypersensitivity to artemether, lumefantrine or to any of the
excipients.
patients with severe malaria according to WHO definition.
patients with a personal or family history of congenital prolongation of the QTc
interval or sudden death, or with any other clinical condition known to prolong the
QTc interval, such as patients with a history of symptomatic cardiac arrhythmias,
clinically relevant bradycardia or severe cardiac diseases.
patients taking drugs that are known to prolong QTc interval such as :
antiarrhythmics of classes IA and III
neuroleptics and antidepressant agents
certain antibiotics including some agents of the following classes: macrolides,
fluoroquinolones, imidazole, and triazole antifungal agents
certain non-sedating antihistamines (terfenadine, astemizole)
cisapride
patients with known disturbances of electrolyte balance e.g. hypokalaemia or
hypomagnesaemia
patients taking any drug which is metabolized by the cytochrome enzyme CYP2D6
(e.g. flecainide, metoprolol, imipramine, amitriptyline, clomipramine
patients taking drugs that are strong inducers of CYP3A4 such as rifampicin,
carbamazepine, phenytoin, St John’s wort
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