Description
- Brand Name: Virest
- Generic Name: Aciclovir
- Virest is a synthetic purine nucleoside with inhibitory activity against herpes simplex virus (HSV-1 & HSV-2) and varicella-zoster virus (VZV).
- Its activity is highly selective due to its affinity for the enzyme thymidine kinase encoded by HSV and VZV.
- Virest is converted into Virest monophosphate, a nucleotide analogue, which further inhibits viral DNA replication in three ways:
- Competitive inhibition of viral DNA polymerase.
- Incorporation into and termination of the growing viral DNA chain.



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